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KMID : 0861020030180010007
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Korea Journal of Herbology
2003 Volume.18 No. 1 p.7 ~ p.13
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Effect of Drynariae Rhizoma on Cultured Mouse Fibroblast Injured by Streptomycin
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Abstract
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Objectives : To examine the cytotoxicity of streptomycin(STR) on cultured mouse fibroblasts, cytotoxocity-induced by STR was measured by MTT assay.
Methods : Fibroblasts were cultured in the media containing various concentrations of STR for 72 hours. In addition, cytoprotective effect of Drynariase Rhizoma(DR) on STR-induced cytotoxicity in fibroblasts was examined when fibroblasts were preincubated with various concentrations of DR for 2 hours before treatment of 5 ㎍/ml STR for 72 hours.
Results : STR decreased remarkably cell viability in a dependentmanner in these cultures, and also DR increased cell viability and amount of DNA synthesis damaged by STR.
Conclusions : From the above results, it is suggested that STR has toxic effect in cultured mouse fibroblasts, and also DR was effective in the protection of STR-induced cytotoxicity in these cultures.
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KEYWORD
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